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pentobarbital will lessen the extent or influence of ethotoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Monitor.pentobarbital will minimize the extent or effect of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Decreased AUC of tramadol and the Energetic metabolite (O-desmethyltra